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This may be indicative of (late) negative feedback regulations on the gene expression level in response to induced Fabp5 expression. Interestingly, we found Nr4a1/Nur77 and Ppard expression in skin significantly decreased or below detection limit in response to those ligands which markedly induced Fabp5 expression, namely the RARα agonist, RAR and RXR antagonists ( and, ). Whether FABP5-mediated PPARδ signaling and/or a novel, as yet undetermined retinoid(s) might mediate such an alternative retinoid pathway in skin is currently under investigation in our laboratory. Et king single collection rar.