SUBSTANCE: group of inventions relates to medicine and deals with immunogenic composition, which contains combination of the following parts: (i). Sergej Mihajlovich Belousov. Serdce drakona, ili Puteshestvie s Pechenyushkinym----- © Copyright Sergej Belousov Email: lizaveta42(a)hotmail.com Date: 16 Apr 2004.
SUBSTANCE: method for producing virus-like particles (VLPs) in a plant is provided, introducing a nucleic acid comprising a regulatory region active in the plant and operably linked to the chimeric nucleotide sequence, into the plant or part of the plant, subsequent incubation of the plant or part thereof under conditions allowing the expression of the nucleic acid to produce a VLP. Virus-like particle (VLP) obtained by this method, a composition and a plant cell containing same are also disclosed. Chimeric nucleotide sequence encodes, in series, an ectodomain from a virus trimeric surface derived from Retroviridae, Rhabdoviridae, Coronaviridae or Filoviridae viruses, fused to the transmembrane domain and the cytoplasmic tail domain (TM/CT) of the influenza virus hemagglutinin. Disclosed VLP contains chimeric viral surface proteins and lipids derived from a plant.
Read and translate the text. Anthrax Anthrax is an acute infectious disease caused by the bacterium Bacillus anthracis and is highly lethal in some forms. Anthrax most commonly occurs in wild and domestic ruminants, but it can also occur in humans when they are exposed to infected animals, tissue from infected animals, or high density of anthrax spores. Anthrax cannot spread from human to human.
Anthrax infection is extremely rare in common domestic pets (dogs and cats). Anthrax is rare in humans although it occasionally occurs in ruminants such as cattle, sheep, goats, camels, and antelopes. Bacillus anthracis bacteria are soil-borne. Anthrax can enter the human body through the intestines, lungs, or skin (cutaneous) and causes distinct clinical syndromes based on its site of entry. An infected human will generally be quarantined. However, anthrax does not usually spread from an infected human to a noninfected human.
Anthrax is usually contracted by handling infected animals or their wool, germ warfare/terrorism or laboratory accidents. Pulmonary (respiratory or inhalation) anthrax.
Respiratory infection initially present with cold or flu-like symptoms for several days, followed by severe (and often fatal) respiratorycollapse. If not treated soon after exposure, before symptoms appear, inhalation anthrax is highlyfatal, with near 100% mortality. Gastrointestinal (gastroenteric) anthrax. Gastrointestinal infection is most often caused by the ingestion of infected meat and often presents with serious gastrointestinal difficulty, vomiting of blood, severe diarrhea, acute inflammation of the intestinal tract, and loss of appetite.
Intestinal infections result in fatality 25 to 60% of the time. Cutaneous (skin) anthrax.
Cutaneous infection is mainfested by progressive stages from an erythematous papule to ulceration and finally to formation of black scar (i.e., eschar). The black eschar often presents with a large, painless necrotic ulcers (beginning as an irritating and itchy skin lesion or blister that is dark and usually concentrated as a black dot, somewhat resembling bread mold) at the site of infection. Cutaneous infection is the least fatal but without treatment, approximately 20% of all skin infection cases may progress to toxemia and death.
Treated cutaneous anthrax is rarely fatal. Treatment for anthrax infection and other bacterial infections includes large doses of intravenous and oral antibiotics, such as, penicillin, ciprofloxacin, doxycycline, erythromycin, and vancomycin. Anthrax spores can survive for long periods of time in the environment after release. Methods for cleaning anthrax contaminated sites commonly use oxidizing agent such as peroxides. These agents slowly destroy bacterial spores. Read and translate the text. Diseases of the sheep Sheep may fall victim to poisons, infectious diseases, and physical injuries.
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There are some obvious signs of ill health, with sick sheep eating little, vocalizing excessively, and being generally listless. In the XX th and XXI st centuries, a minority of sheep owners have turned to alternative treatments such as homeopathy, herbalism and even traditional Chinese medicine to treat sheep veterinary problems. The need for traditional anti-parasitedrugs and antibiotics is widespread, and is the main impediment to certified organic farming with sheep.
Many breeders take a variety of preventative measures to warn off problems. The first is to ensure that all sheep are healthy when purchased. Many buyers avoid outlets known to be clearing houses for animals culled from healthy flocks as either sick or simply inferior. This can also mean maintaining a closed flock, and quarantining new sheep for a month. Two fundamental preventative programs are maintaining good nutrition and reducing stress in the sheep. Handling sheep in loud, erratic ways causes them to produce cortisol, a stress hormone. This can lead to a weakened immune system, thus making sheep far more vulnerable to disease.